Rogers E. M. Diffusion of Innovations, 5th edn, (Free Press, 2003).
Hanna, M. G. et al. Whole slide imaging equivalency and efficiency study: experience at a large academic center. Mod. Pathol. 32, 916–928 (2019).
Hanna, M. G. et al. Validation of a digital pathology system including remote review during the COVID-19 pandemic. Mod. Pathol. 33, 2115–2127 (2020).
Weinstein, R. S., Holcomb, M. J. & Krupinski, E. A. Invention and Early History of Telepathology (1985-2000). J. Pathol. Inform. 10, 1 (2019).
Park, S. et al. The history of pathology informatics: a global perspective. J. Pathol. Inf. 4, 7 (2013).
Pantanowitz, L. et al. Twenty years of digital pathology: an overview of the road travelled, what is on the horizon, and the emergence of vendor-neutral archives. J. Pathol. Inform. 9, 40 (2018).
Farahani, N., Parwani, A. V. & Pantanowitz, L. Whole slide imaging in pathology: advantages, limitations, and emerging perspectives. Pathol. Lab. Med. Int. 7, 23–33 (2015).
Hanna, M. G. et al. Implementation of digital pathology offers clinical and operational increase in efficiency and cost savings. Arch. Pathol. Lab. Med. 143, 1545–1555 (2019).
Hanna, M. G. & Pantanowitz, L. Bar coding and tracking in pathology. Surg. Pathol. Clin. 8, 123–135 (2015).
Slaw, R. J. et al. Doctor, We Shrunk the Cost (and the Tissue)! How Digitizing Control Slides Led to Cost Savings and Tissue Size Reduction. J Pathol Inform 8, 20 (2017).
Zarella, M. D. et al. A practical guide to whole slide imaging: a white paper from the digital pathology association. Arch. Pathol. Lab. Med. 143, 222–234 (2019).
Randell, R., Ruddle, R. A. & Treanor, D. Barriers and facilitators to the introduction of digital pathology for diagnostic work. Stud. Health Technol. Inform. 216, 443–447 (2015).
Browning, L. et al. Implementation of digital pathology into diagnostic practice: perceptions and opinions of histopathology trainees and implications for training. J. Clin. Pathol. 73, 223–227 (2020).
Retamero, J. A., Aneiros-Fernandez, J., Del & Moral, R. G. Complete digital pathology for routine histopathology diagnosis in a multicenter hospital network. Arch. Pathol. Lab. Med. 144, 221–228 (2020).
Fraggetta, F., Garozzo, S., Zannoni, G. F., Pantanowitz, L. & Rossi, E. D. Routine digital pathology workflow: the Catania experience. J. Pathol. Inform. 8, 51 (2017).
College of American Pathologists (2020) Policy PP. Minimum period of retention of laboratory records and materials, (CAP) https://elss.cap.org/elss/ShowProperty?nodePath=/UCMCON/Contribution%20Folders/WebApplications/pdf/retention-laboratory-records-and-materials.pdf (accessed 13 April 2021).
Hanna, M. G., Parwani, A. & Sirintrapun, S. J. Whole slide imaging: technology and applications. Adv. Anat. Pathol. 27, 251–259 (2020).
Baskota, S. U., Wiley, C. & Pantanowitz, L. The next generation robotic microscopy for intraoperative teleneuropathology consultation. J. Pathol. Inform. 11, 13 (2020).
Sirintrapun, S. J. et al. Robotic telecytology for remote cytologic evaluation without an on-site cytotechnologist or cytopathologist: a tale of implementation and review of constraints. J. Pathol. Inform. 8, 32 (2017).
Sirintrapun, S. J. et al. Robotic telecytology for remote cytologic evaluation without an on-site cytotechnologist or cytopathologist: an active quality assessment and experience of over 400 cases. J. Pathol. Inform. 8, 35 (2017).
Dunn, B. E. et al. Dynamic-robotic telepathology: department of veterans affairs feasibility study. Hum. Pathol. 28, 8–12 (1997).
Dunn, B. E., Choi, H., Recla, D. L., Kerr, S. E. & Wagenman, B. L. Robotic surgical telepathology between the Iron Mountain and Milwaukee Department of Veterans Affairs Medical Centers: a 12-year experience. Hum. Pathol. 40, 1092–1099 (2009).
Evans, A. J. et al. Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience. Semin. Diagn. Pathol. 26, 165–176 (2009).
Leong, F. J. W.-M., Nicholson, A. G. & McGee, J. O. Robotic telepathology: efficacy and usability in pulmonary pathology. J. Pathol. 197, 211–217 (2002).
Menter, T., Nicolet, S., Baumhoer, D., Tolnay, M. & Tzankov, A. Intraoperative frozen section consultation by remote whole-slide imaging analysis -validation and comparison to robotic remote microscopy. J. Clin. Pathol. 73, 350–352 (2020).
Thrall, M. J., Rivera, A. L., Takei, H. & Powell, S. Z. Validation of a novel robotic telepathology platform for neuropathology intraoperative touch preparations. J. Pathol. Inform. 5, 1 (2014).
Pradhan, D. et al. Evaluation of panoramic digital images using Panoptiq for frozen section diagnosis. J. Pathol. Inform. 7, 26 (2016).
Roy, S. et al. Smartphone adapters for digital photomicrography. J. Pathol. Inform. 5, 24 (2014).
Groen, R. et al. Application of microscope-based scanning software (Panoptiq) for the interpretation of cervicovaginal cytology specimens. Cancer Cytopathol. 125, 918–925 (2017).
Hanna, M. G. et al. Comparison of glass slides and various digital-slide modalities for cytopathology screening and interpretation. Cancer Cytopathol. 125, 701–709 (2017).
Lin, O., Rudomina, D., Feratovic, R. & Sirintrapun, S. J. Rapid on-site evaluation using telecytology: a major cancer center experience. Diagn. Cytopathol. 47, 15–19 (2019).
Clunie, D. et al. Digital imaging and communications in medicine whole slide imaging connectathon at digital pathology association pathology visions 2017. J. Pathol. Inform. 9, 6 (2018).
Janowczyk, A., Zuo, R., Gilmore, H., Feldman, M. & Madabhushi, A. HistoQC: an open-source quality control tool for digital pathology slides. JCO Clin. Cancer Inform. 3, 1–7 (2019).
Chen, Y. et al. Assessment of a computerized quantitative quality control tool for whole slide images of kidney biopsies. J. Pathol. 253, 268–278 (2021).
Molin, J., Lundström, C. & Fjeld, M. A comparative study of input devices for digital slide navigation. J. Pathol. Inform. 6, 7 (2015).
Mateos E. A. et al. Research on Devices for Handling Whole Slide Images on Pathology Workstations. An Ergonomic Outlook. Diagn Pathol 2: (2016)
Kim, D. et al. (Re) Defining the high-power field for digital pathology. J. Pathol. Inform. 11, 33 (2020).
Abel, J. T. et al. Display characteristics and their impact on digital pathology: a current review of pathologists’ future ‘microscope’. J. Pathol. Inform. 11, 23 (2020).
Clarke, E. L., Munnings, C., Williams, B., Brettle, D. & Treanor, D. Display evaluation for primary diagnosis using digital pathology. J. Med. Imaging Bellingham Wash 7, 027501 (2020).
Williams, B. J., Bottoms, D. & Treanor, D. Future-proofing pathology: the case for clinical adoption of digital pathology. J. Clin. Pathol. 70, 1010–1018 (2017).
Luo, W. & Hassell, L. A. Use cases for digital pathology. In Digital Pathology: Historical Perspectives, Current Concepts & Future Applications, (eds Kaplan, K. J. & Rao, L. K. F.) pp. 5–15 (Springer International Publishing, 2016).
Jahn, S. W., Plass, M. & Moinfar, F. Digital pathology: advantages, limitations and emerging perspectives. J. Clin. Med. 9, 3697 (2020).
Niazi, M. K. K., Parwani, A. V. & Gurcan, M. N. Digital pathology and artificial intelligence. Lancet Oncol. 20, e253–e261 (2019).
Tizhoosh, H. R. & Pantanowitz, L. Artificial intelligence and digital pathology: challenges and opportunities. J. Pathol. Inform. 9, 38 (2018).
Higgins, C. Applications and challenges of digital pathology and whole slide imaging. Biotech. Histochem. 90, 341–347 (2015).
Pallua, J. D., Brunner, A., Zelger, B., Schirmer, M. & Haybaeck, J. The future of pathology is digital. Pathol. Res. Pract. 216, 153040 (2020).
Volynskaya, Z. et al. Integrated pathology informatics enables high-quality personalized and precision medicine: digital pathology and beyond. Arch. Pathol. Lab. Med. 142, 369–382 (2018).
Lujan, G. et al. Dissecting the business case for adoption and implementation of digital pathology: a white paper from the digital pathology association. J. Pathol. Inform. 12, 17 (2021).
Williams, B. J., Bottoms, D., Clark, D. & Treanor, D. Future-proofing pathology part 2: building a business case for digital pathology. J. Clin. Pathol. 72, 198–205 (2019).
Ho, J. et al. Can digital pathology result in cost savings? A financial projection for digital pathology implementation at a large integrated health care organization. J. Pathol. Inform. 5, 33 (2014).
Evans, A. J., Vajpeyi, R., Henry, M. & Chetty, R. Establishment of a remote diagnostic histopathology service using whole slide imaging (digital pathology). J. Clin. Pathol. 74, 421–424 (2020).
Baidoshvili, A. et al. Evaluating the benefits of digital pathology implementation: time savings in laboratory logistics. Histopathology 73, 784–794 (2018).
Chong, T. et al. The California Telepathology Service: UCLA’s experience in deploying a regional digital pathology subspecialty consultation network. J. Pathol. Inform. 10, 31 (2019).
Thrall, M. J., Wimmer, J. L. & Schwartz, M. R. Validation of multiple whole slide imaging scanners based on the guideline from the College of American Pathologists Pathology and Laboratory Quality Center. Arch. Pathol. Lab. Med. 139, 656–664 (2015).
Mills, A. M. et al. Diagnostic efficiency in digital pathology: a comparison of optical versus digital assessment in 510 surgical pathology cases. Am. J. Surg. Pathol. 42, 53–59 (2018).
Raciti, P. et al. Novel artificial intelligence system increases the detection of prostate cancer in whole slide images of core needle biopsies. Mod. Pathol. 33, 2058–2066 (2020).
da Silva, L. M. et al. Independent real-world application of a clinical-grade automated prostate cancer detection system. J. Pathol. 254, 147–158 (2021).
Pantanowitz, L. et al. Accuracy and efficiency of an artificial intelligence tool when counting breast mitoses. Diagn. Pathol. 15, 80 (2020).
Pantanowitz, L. et al. Artificial intelligence-based screening for mycobacteria in whole-slide images of tissue samples. Am. J. Clin. Pathol. 156, 117–128 (2021).
Pantanowitz, L. et al. Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center. Arch. Pathol. Lab. Med. 137, 1710–1722 (2013).
Evans, A. J. et al. Validating whole slide imaging systems for diagnostic purposes in pathology: guideline update from the College of American Pathologists in Collaboration With the American Society for Clinical Pathology and the Association for Pathology Informatics. Arch. Pathol. Lab. Med. (2021). Epub ahead of print.
Araújo, A. L. D. et al. Fully digital pathology laboratory routine and remote reporting of oral and maxillofacial diagnosis during the COVID-19 pandemic: a validation study. Virchows Arch. 479, 585–595 (2021).
Zelic, R. et al. Interchangeability of light and virtual microscopy for histopathological evaluation of prostate cancer. Sci Rep. 11, 3257 (2021).
Diniz, P.-B. et al. Comparison of the whole slide imaging and conventional light microscopy in the grading of oral epithelial dysplasia: a multi-institutional study. Med. Oral Patol. Oral Cir. Bucal 26, e8–e13 (2021).
Alassiri, A. et al. Whole slide imaging compared with light microscopy for primary diagnosis in surgical neuropathology: a validation study. Ann. Saudi Med. 40, 36–41 (2020).
Al Habeeb, A., Evans, A., Ghazarian, D. Virtual microscopy using whole-slide imaging as an enabler for teledermatopathology: a paired consultant validation study. J. Pathol. Inform. 3, 2 (2012).
Araújo, A. L. D. et al. Validation of digital microscopy in the histopathological diagnoses of oral diseases. Virchows Arch. 473, 321–327 (2018).
Bauer, T. W. et al. Validation of whole slide imaging for primary diagnosis in surgical pathology. Arch Pathol. Lab. Med. 137, 518–524 (2013).
Brunelli, M. et al. iPathology cockpit diagnostic station: validation according to College of American Pathologists Pathology and Laboratory Quality Center recommendation at the Hospital Trust and University of Verona. Diagn. Pathol. 9(Suppl 1), S12 (2014).
Buck, T. P., Dilorio, R., Havrilla, L. & O’Neill, D. G. Validation of a whole slide imaging system for primary diagnosis in surgical pathology: a community hospital experience. J. Pathol. Inform. 5, 43 (2014).
Fónyad, L. et al. Validation of diagnostic accuracy using digital slides in routine histopathology. Diagn. Pathol. 7, 35 (2012).
Jukić, D. M., Drogowski, L. M., Martina, J. & Parwani, A. V. Clinical examination and validation of primary diagnosis in anatomic pathology using whole slide digital images. Arch. Pathol. Lab. Med. 135, 372–378 (2011).
Mpunga, T. et al. Implementation and Validation of Telepathology Triage at Cancer Referral Center in Rural Rwanda. J. Glob. Oncol. 2, 76–82 (2016).
Campbell, W. S. et al. Concordance between whole-slide imaging and light microscopy for routine surgical pathology. Hum. Pathol. 43, 1739–1744 (2012).
Cheng, C. L. et al. Enabling digital pathology in the diagnostic setting: navigating through the implementation journey in an academic medical centre. J. Clin. Pathol. 69, 784–792 (2016).
Goacher, E., Randell, R., Williams, B. & Treanor, D. The diagnostic concordance of whole slide imaging and light microscopy: a systematic review. Arch. Pathol. Lab. Med. 141, 151–161 (2017).
Houghton, J. P. et al. Concordance between digital pathology and light microscopy in general surgical pathology: a pilot study of 100 cases. J. Clin. Pathol. 67, 1052–1055 (2014).
Mukhopadhyay, S. et al. Whole slide imaging versus microscopy for primary diagnosis in surgical pathology. Am. J. Surg. Pathol. 42, 39–52 (2018).
Snead, D. R. J. et al. Validation of digital pathology imaging for primary histopathological diagnosis. Histopathology 68, 1063–1072 (2016).
Tabata, K. et al. Whole-slide imaging at primary pathological diagnosis: validation of whole-slide imaging-based primary pathological diagnosis at twelve Japanese academic institutes. Pathol. Int. 67, 547–554 (2017).
Al-Janabi, S. et al. Whole slide images for primary diagnostics of urinary system pathology: a feasibility study. J. Ren. Inj. Prev. 3, 91–96 (2014).
Arnold, M. A. et al. The College of American Pathologists guidelines for whole slide imaging validation are feasible for pediatric pathology: a pediatric pathology practice experience. Pediatr. Dev. Pathol. 18, 109–116 (2015).
Campbell, W. S. et al. Whole slide imaging diagnostic concordance with light microscopy for breast needle biopsies. Hum. Pathol. 45, 1713–1721 (2014).
Krishnamurthy, S. et al. Multi-institutional comparison of whole slide digital imaging and optical microscopy for interpretation of hematoxylin-eosin-stained breast tissue sections. Arch. Pathol. Lab. Med. 137, 1733–1739 (2013).
Ordi, J. et al. Validation of whole slide imaging in the primary diagnosis of gynaecological pathology in a University Hospital. J. Clin. Pathol. 68, 33–39 (2015).
Reyes, C., Ikpatt, O. F., Nadji, M. & Cote, R. J. Intra-observer reproducibility of whole slide imaging for the primary diagnosis of breast needle biopsies. J. Pathol. Inform. 5, 5 (2014).